By Laurence Klotz M.D., F.R.C.S.C. (auth.), Laurence Klotz (eds.)
Active Surveillance for Localized Prostate melanoma: a brand new Paradigm for medical administration will function an invaluable source for physicians facing, and drawn to, this advanced and evolving department of prostate melanoma administration. The e-book can also be of curiosity to scientifically literate sufferers and their households. the amount presents an creation to the concept that of lively surveillance in oncology commonly and prostate melanoma in particular. the first concentration is to supply a complete consultant to the administration of sufferers on surveillance. the amount covers the various complexities and nuances to this strategy together with, sufferer choice, threat overview, easy methods to triumph over 'cancer hysteria' whilst counseling sufferers, selecting acceptable triggers for intervention, use of PSA kinetics and MR imaging details, approach and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.
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Additional info for Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management
Germline BRCA mutations denote a clinicopathologic subset of prostate cancer. Clin Cancer Res. 2010 Apr 1; 16(7):2115–21. 20. Mani RS, Tomlins SA, Callahan K, et al. Induced chromosomal proximity and gene fusions in prostate cancer. Science. 2009 Nov 27;326(5957):1230. 21. Cuzick J, Swanson GP, Fisher G, et al. Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study. Lancet Oncol. 2011 Mar;12(3):245–55. 22.
Howard DH. Life expectancy and the value of early detection. J Health Econ. 2005 Sep;24(5):891–906. 76. Period Life Table, 2006. html]. 77. Clayton DB, Urban DA. Point: the value of predicting life expectancy in men with clinically localized prostate cancer. J Natl Compr Canc Netw. 2007 Aug;5(7):703–8. 78. Steineck G, Helgesen F, Adolfsson J, et al. Quality of life after radical prostatectomy or watchful waiting. N Engl J Med. 2002 Sep 12;347(11):790–6. 21 79. Litwin MS, Lubeck DP, Spitalny GM, Henning JM, Carroll PR.
More studies, preferably multicenter, evaluating these prognostic markers in well-defined patient cohorts are required to understand the importance of TMPRSS2 translocation with clinically significant disease. 26 A recently described LNCaP cell model has identified a novel mechanism for the development of a TMPRSS2 translocation in prostate cancer . By subjecting LNCaP cells to both androgens (dihydrotesterone, DHT) and irradiation (IR), several gene fusions including TMPRSS2-ERGb were induced.