By Michel Burnier, Robert W. Schrier (auth.), Alberto Amerio, Pasquale Coratelli, Vito M. Campese, Shaul G. Massry (eds.)
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72: 128-141, 1983. , D'Agostini, R. , Freedman, M. , Scott, W. W. , Siegelman, S. S. and Heptinstall, R. : Beneficial effect of propranolol in a histologically appropriate model of postischemic acute renal failure. AMER. J. PATHOL. 88: 163, 1977. , Dohoux, P. and Sraer, J. : The pathology of acute renal failure due to interstitial nephritis in man with comments on the role of interstitial inflammation and sex in gentamicin nephrotoxicity. MEDICINE 61: 258, 1982. , Silva, P. : Renal ischemia: A new perspective.
45: 378, 1981. Dobyan, D. , Nagle, R. B. and Bulger, R. : Aeute tubular neerosis in the rat kidney following sustained hypotension. Physiologie and morphologie observations. LAB. INVEST. 37: 411, 1977. Raeusen, L. C. : Podoeyte ehanges in post-isehemie ARF. In: ACUTE RENAL FAllURE: Correlations Between Morphology and Funetion; edited by: Solez, K. , 1984, pp. 134-145. 25 LONG TERM CLINICAL AND MORPHOLOGICAL EVALUATION OF ACUTE RENAL FAlLURE V. Bonomini, A. Vangelista, G. Frasca, S. P. Scolari, and G.
After the substitution of corticosterone in BN/ADX animals these benefical biochemical effects were readily reversed (Fig. 4). animals, It is of note that in BN/ADX blood levels of ionized calcium were significantly increased. Administration of corticosterone readily reversed t hi s phe nome non. 1000 '0 "CI ~ Gi c:: .. >. c GI ::::Il, C') Fig. 4: Effect of ADX on serum levels of 3-methyl- hlstidlne 48 hours after induction of uremia. details, see legend to Fig. For 3. These data clearly indicate that glucocorticoids playa major role in the enhanced muscle protein degradation of acute uremia.