Download Angiogenesis: Models, Modulators, and Clinical Applications by Michael E. Maragoudakis (auth.), Michael E. Maragoudakis PDF

By Michael E. Maragoudakis (auth.), Michael E. Maragoudakis (eds.)

ISBN-10: 1475791879

ISBN-13: 9781475791877

Interest in angiogenesis learn continues to be robust lately and interesting new discoveries, approximately modulators of angiogenesis, their receptors, the transduction mechanisms and the angiogenic genes concerned, have contributed to our trendy knowing of this complicated method. this information has supplied the foundation and broadened the scope of angiogenesis - dependent remedy in oncology and plenty of different scientific stipulations. This monograph includes the contributions to the NATO complex examine Institute on "Angiogenesis: versions, Modulators and medical Applications", which used to be held in Rhodes, Greece, from June 20-30, 1997. This was once the fourth of a sequence of NATO supported overseas conferences on Angiogenesis aiming to compile uncomplicated scientists with clinicians to replace rules, disseminate new wisdom and talk about the current prestige and strength new instructions during this fast paced region of biomedical learn. The overseas setting up Committee that integrated Drs. E. Dejana, C Haudenschild, M. Hackel, H. Kleinman, P. Lelkes, M. Presta, P. Polverini, D. Thompson, has supplied important support with their insightful feedback within the formula of the clinical application for which i'm thankful. I desire to thank the entire contributors for his or her enthusiastic participation and their complimentary reviews at the good fortune of the conference.

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1. Exp. Path. 74:65-71. Denekamp, l, 1984, Vasculature as a target for tumour therapy, Progr. Appl. Microcirc. 4:28-38. , 1992, Effect of long-tenn muscle overload on capillary supply, blood flow and performance in rat fast muscle, 1. , Lond. 452:9P. , 1991, Adaptation of rat extensor digitorum longus to overload and increased activity, Pflugers Arch. 419:319-326. , 1994, The effect of alpha 1 blocker prazosin on capillarization, blood flow and perfonnance in ischaemic skeletal muscles, Int. 1.

Bosia, P. Marchisio and A. Mantovani. In vitro and in vivo activation of endothelial cells by colony-stimulating factors. 1. Clin. , 87: 986-995, 1991. F. Di Renzo, M. Ziche, E. Bocchietto, M. Oliviero, L. Naldini, G. Gaudino, L. Tamagnone, A. c. M. Comoglio. Hepatocyte 44 growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. 1. , 119(3): 629-641,1992. -T. , S. Donnini, M. liche and R. Bicknell. An angiogenic role for the neurotrophins midkine and pleiotrophin in tumorigenesis.

In the heart, the most powerful stimulus is a drastic reduction of heart rate achieved either by electrical bradycardial pacing or drugs with a relatively specific negative chronotropic effect, but substantial capillary growth can be achieved by long-tenn administration of drugs with a positive inotropic effect. The mechanism of capillary growth is linked with various mechanical factors such as shear stress or stretch of the capillary wall. Capillary growth in tissues with limited blood supply has a beneficial effect on blood flow and perfonnance.

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