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Hands-on laboratory specialists describe for the beginner investigator a number of novel applied sciences and molecular strategies particularly designed to check mobile immunology and advertise its gene treatment functions. awarded in step by step element to make sure prepared reproducibility, those protocols variety from circulate cytometric concepts to notice cytokines and progress components in several specimens, to tools for producing and increasing dendritic cells and hematopoietic progenitors from varied origins.
The fowl is an invaluable version for learn into the elemental gains of immunology simply because its immune procedure services in a fashion just like that of humans and as the fowl embryo is well accessed experimentally. This booklet is a set of comprehen sive articles updating bird embryogenesis and immunology.
This new version provides major new fabric detailing molecular recommendations utilized in the sphere. presents a entire and useful method of the tactics underlying medical immunology checking out; good points new emphasis on molecular thoughts utilized in the sector; positive factors new emphasis on molecular concepts utilized in the sector; and covers person attempt varieties, mobile and humoral scientific symptoms, person pathogenic organisms, allergic reaction, autoimmune ailments, cancers, and transplantation immunology.
Exploring the debate surrounding healing human cloning, this e-book attracts upon facts accumulated from information articles and interviews with newshounds to check the function of mass media in shaping biomedical controversies. With particular connection with the USA and the united kingdom as prime clinical countries grappling with the worldwide factor of healing cloning, including recognition to the $64000 function performed by way of countries in Southeast Asia, this publication sheds gentle on media representations of medical advancements, the unrealistic hype which may encompass them, the effect of faith and the doubtless damaging imposition of journalistic and nationalist values at the medical box.
Additional info for Annual Review of Immunology Volume 22 2004
Natl. Acad. Sci. 104558 Annu. Rev. Immunol. 2004. 104558 Copyright c 2004 by Annual Reviews. All rights reserved First published online as a Review in Advance on September 15, 2003 Annu. Rev. Immunol. 22:33-54. org by HINARI on 09/01/07. For personal use only. H. Geijtenbeek,1 Sandra J. van Vliet,1 Anneke Engering,1 Bert A. nl 2 Department of Immunobiology, Biomedical Primate Research Center, 2280 GH Rijswijk, Netherlands 3 Department of Immunology, Erasmus Medical Centre, 3015 GE Rotterdam, Netherlands Key Words DC-SIGN, carbohydrates, antigen recognition, pathogen, dendritic cells ■ Abstract Dendritic cells (DCs) are highly efficient antigen-presenting cells (APCs) that collect antigen in body tissues and transport them to draining lymph nodes.
For some C-type lectins, internalization of CLR-specific murine IgG antibodies was shown to lead to antigen presentation to murine IgG-specific CD4+ T cells. Most C-type lectins containing a tri-acidic cluster (DEC-205, DC-SIGN, BDCA-2, Dectin-1, and CLEC-1) target internalized antigens to lysosomes and MHC class II+ late endosomes (Figure 1) (20, 55). In contrast, other C-type lectins, such as the MR, quickly recycle via early endosomes to ensure uptake of large amounts of antigen (Figure 1) (19).
Tuberculosis, the immune response is driven toward immunosuppression by the induction of IL-10 and the inhibition of DC maturation. These studies demonstrate that the collaborative recognition of distinct microbial components by different classes of innate immune receptors (CLRs and TLRs) is crucial for orchestrating inflammatory or inhibitory responses. The balance between TLR stimulation and C-type lectin occupation may fine-tune regulatory mechanisms to allow appropriate immune responses. The inflammatory and pathogenic consequence of this recognition is dependent on both the receptor repertoire and the functional cooperation between the signals generated downstream of receptor-ligand interaction.