Download Antibodies for infectious diseases by James E., Jr. Crowe, Diana Boraschi, Rino Rappuoli PDF

By James E., Jr. Crowe, Diana Boraschi, Rino Rappuoli

ISBN-10: 1555817351

ISBN-13: 9781555817350

State-of-the-art studies protecting significant elements of antibodies and intervention opposed to infectious diseases

The connection among antibodies and infectious illnesses has spawned complete similar fields of analysis. Antibodies for Infectious Diseases offers views from major learn scientists and summarizes the fantastic growth during this region right into a unmarried definitive resource.

Providing a huge survey of an important facets of the sphere of antibodies for infectious ailments, this book

  • presents basic beneficial properties touching on constitution, functionality, isotype, and the function of supplement in antibody function
  • examines the function of antibodies in antimicrobial immunity with particular targets
  • details new equipment for expression of monoclonal antibodies, in vegetation or by means of move of antibody genes for in vivo expression in taken care of subjects

Antibodies for Infectious Diseases is a finished reference for researchers, pharmaceutical builders, and well-being care execs at the prestige of the improvement of antibody-based treatments for treating infectious ailments. it's also precious as supplemental interpreting for top point lifestyles sciences scholars.

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Extra info for Antibodies for infectious diseases

Sample text

For example, an antibody against human rhinovirus type 14 binds to surrounding viral structures but nonetheless sterically hinders interactions between the virus and its intercellular adhesion molecule-1 host receptor (26). The stoichiometry of antibody-antigen interactions required for neutralization has been studied for many viruses, and evidence supports a “multiple hit” phenomenon in which neutral- 27 ization requires the engagement of more than one antibody on the virion (27). Both antibody affinity and the accessibility of epitopes on the organism are the critical factors in determining whether antibody binding will exceed the threshold required for neutralization.

2001. Effector function activities of a panel of mutants of a 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. broadly neutralizing antibody against human immunodeficiency virus type 1. J Virol 75: 12161–12168. Hessell AJ, Hangartner L, Hunter M, Havenith CD, Beursken FJ, Bakker JM, Lanigan CM, Landucci G, Forthal DN, Parren PW, Marx PA, Burton DR. 2007. Fc receptor but not complement binding is important in antibody protection against HIV. Nature 449(7158):101–104. Dall’Acqua WF, Kiener PA, Wu H. 2006.

9. Berry JD, Gaudet RG. 2011. Antibodies in infectious diseases: polyclonals, monoclonals and niche biotechnology. New Biotechnol 28:489–501. 10. Cauza K, Hinterhuber G, DingelmaierHovorka R, Brugger K, Klosner G, Horvat R, Wolff K, Foedinger D. 2005. Expression of FcRn, the MHC class I-related receptor for IgG, in human keratinocytes. J Invest Dermatol 124:132–139. 11. Marasco WA, Sui J. 2007. The growth and potential of human antiviral monoclonal antibody therapeutics. Nat Biotechnol 25:1421– 1434.

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