By Lesley McGee, Keith P. Klugman (auth.), Douglas L. Mayers MD (eds.)
The volumes incorporated in Antimicrobial Drug Resistance signify the 1st accomplished, multidisciplinary reference masking the world of antimicrobial drug resistance in micro organism, fungi, viruses, and parasites from easy technological know-how, medical, and epidemiological perspectives.
The first quantity, Antimicrobial Drug Resistance, Mechanisms of Drug Resistance, is devoted to the organic foundation of drug resistance and powerful avenues for drug improvement. With the emergence of extra drug-resistant lines, the method of facing the drug resistance challenge needs to comprise the examine of other facets of the mechanisms of bacterial resistance and the dissemination of resistance genes in addition to examine using new genomic details. those techniques will let the layout of novel options to advance new antibiotics and guard the effectiveness of at the moment on hand ones.
The moment quantity, Antimicrobial Drug Resistance, medical and Epidemiological Aspects, is dedicated to the scientific elements of drug resistance. even though there's proof that constrained use of a particular antibiotic may be by way of a lessen in drug resistance to that agent, drug resistance keep watch over isn't really simply accomplished. therefore, the infectious ailment doctor calls for enter from the scientific microbiologist and an infection regulate professional to make expert offerings for the potent remedy of varied lines of drug-resistant pathogens in person patients.
This 2-volume set is a crucial reference for college kids in microbiology, infectious illness physicians, clinical scholars, easy scientists, drug improvement researchers, microbiologists, epidemiologists, and public future health practitioners.
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Extra info for Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects
5 Groups C and G Beta-Hemolytic Streptococci Most of the Lancefield group C streptococci (GCS) produce beta-haemolysis on blood agar although non-hemolytic strains also exist. GCS are mainly animal pathogens. Group C beta-hemolytic streptococci have been isolated from human normal microbiota of nasopharynx, skin and genital tract. Of the four group C streptococci species S. equisimilis is the most common human isolate (2). Most of the group G streptococci (GGS) are beta-haemolytic. As GCS, they are also found in human normal microbiota of nasopharynx, skin and genital tract.
Trimethoprim and sulfamethoxazole are used extensively in combination as the drug ‘co-trimoxazole’. Cotrimoxazole has been used in the treatment of a range of S. pneumoniae 47 Resistance in Streptococcus pneumoniae diseases, especially in children, because it is inexpensive and generally effective. Resistance to cotrimoxazole has increased dramatically in many regions of the world and recent surveillance studies show rates ranging from 19% in Europe to around 50% associated with HIV infection in Africa and >60% in Asia (22, 140, 141).
Structure and dissemination of a chromosomal insertion element encoding macrolide efflux in Streptococcus pneumoniae. J Infect Dis 2001;184:56–65 Del Grosso M, Iannelli F, Messina C, et al. Macrolide efflux genes mef(A) and mef(E) are carried by different genetic elements in Streptococcus pneumoniae. J Clin Microbiol 2002;40:774–778 Santagati M, Iannelli F, Oggioni MR, Stefani S, Pozzi G. Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae.