Download Antimicrobial Peptides: Role in Human Health and Disease by Jürgen Harder, Jens-M. Schröder PDF

By Jürgen Harder, Jens-M. Schröder

ISBN-10: 3319241974

ISBN-13: 9783319241975

This publication specializes in the significance of human antimicrobial peptides (AMP) in preserving the host fit and fighting infectious illnesses. the 1st chapters take care of a number of examples of the position of AMP in several epithelial organs (skin and wound therapeutic, eye, lung, genito-urinary tract, gut), that are uncovered to other kinds of infectious microorganisms and accordingly produce various styles of AMP. Examples of the dysregulation of AMP expression and serve as selling infections are mentioned. The ability of AMP to limit the supply of crucial metals to micro organism as a good antibacterial technique in dietary immunity is mentioned within the subsequent bankruptcy. Our present figuring out of ways nutrition D, the light diet, affects AMP-expression and the way this may impact our overall healthiness can also be addressed. final yet no longer least, the function of AMP in HIV an infection and the immunomodulatory homes of AMP spotlight the various points of AMP in host immunity. AMP’s particular capabilities, together with in combating multi-resistant micro organism, recommend that they might provide healing advantages – a question that's mentioned within the ultimate chapter.

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Additional resources for Antimicrobial Peptides: Role in Human Health and Disease

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Graefe’s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle. Ophthalmologie 244:143–148 Pillay K, Coutsoudis A, Agadzi-Naqvi AK et al (2001) Secretory leukocyte protease inhibitor in vaginal fluids and perinatal human immunodeficiency virus type 1 transmission. J Infect Dis 183:653–656 Qu XD, Lehrer RI (1998) Secretory phospholipase A2 is the principal bactericide for staphylococci and other gram-positive bacteria in human tears. Infect Immun 66:2791–2797 Rowe AM, St Leger AJ, Jeon S et al (2013) Herpes keratitis.

AMPs qualify as mediators of wound healing and tissue repair as the expression of AMPs by inflammatory and epithelial cells is increased under infectious and inflammatory conditions and epithelial injury induced by infectious agents leads to an increased risk that pathogens invade the host (Steinstraesser et al. 2008; Lai and Gallo 2009). Indeed, there is strong evidence that AMPs are involved in epithelial repair processes, such as cell proliferation, epithelial regeneration, and reepithelialization (Lai and Gallo 2009; Heilborn et al.

Cell Tissue Res 343:175–188 Hazrati E, Galen B, Lu W et al (2006) Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection. J Immunol 177:8658–8666 Huang LC, Reins RY, Gallo RL et al (2007) Cathelicidin-deficient (Cnlp -/-) mice show increased susceptibility to Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci 48:4498–4508 Jang SA, Kim H, Lee JY et al (2012) Mechanism of action and specificity of antimicrobial peptides designed based on buforin IIb. Peptides 34:283–289 Karsten E, Watson SL, Foster LJ (2012) Diversity of microbial species implicated in keratitis: a review.

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